The word fasad and its derivations have been mentioned in 50 cases of the holy Quran. It has not been studied with a semantic and interconnected approach. This paper has studied the word with a descriptive semantics method. Frequent emphasis on avoiding fasad on the earth shows the attention of the Quran to human social life. A notable fact in the field lies in its being qualitatively and quantitatively accompanied by salah. On the Quranic teachings, human life is based on order and salah, God, the Exalted, therefore, has supported salihan and opposed mufsidan and invited people to think about the end of fasidn. And considering them paradigmatically, every case of fasad, with a cruel approach is followed by destroying a case of right and justice. Again, the word kufr is equal to fasad, since lack of belief in the existence of a reforming designer for universe is the base for all mafased. Therefore, the essence of every fasad is sin and devilry.