The Holy Quran’s ontological foundations about interpreting the ranking of the worldly creatures are different from the prevalent view attributed to Aristotle. According to Quran, the ranking of creatures depends upon the amount of nearness of each creature to God. Based on this assumption, human will not be the noblest of the creatures, and even if this condition is not realized in a man, he will be like animals or even lower than that. There are verses being discussed by Allame Tabatabaie among which are the ones about “human misguidance compared to animals”. Having analyzed the probabilities in interpretive discourse of Allameh about the discussed verses, the study attempts to discover his final viewpoint in Tafsir Al-Mizan about two main topics on “similarity of some people to animals” and also on “how some people will turn inferior to animals”. In general, four probabilities could be inferred from Allameh Tabatabaie’s viewpoint in this commentary. It appears that some of these probabilities could be retractable by no means and not being compatible with his viewpoint in commentary of the similar verses