"Resistance" is one of the fundamental and innate words of Quranic origin that has a significant relationship with the Quranic social concepts and verses. According to the literal and interpretive implications, it can be known equal to monotheism, justice and, ultimately, Islam. This essential and notable word, however, has misunderstood so that the methods of resistance such as confrontation, war and assassination are meant by it. Has been. The purpose of this study is to develop the semantic and interpretive "resistance" and to reveal the capacity of Islam in responding to social needs and to confront the "Western thought" which is very effective in realizing and strengthening the political and social system of Islam. Resistance in the Qur'an is based on monotheism, justice and innate nature and emphasizes the fulfillment of God's sovereignty over human destiny, the formation of government, installment, land development and non-acceptance of guardianship of non-Divine servitude.