The current research is an attempt to inquire into the anthropological verses of Quran to infer the teachings interchangeable with cognitive deviations giving birth to depression. These teachings advise man of his eminent position in the universe and, as a result, such a man would not be plagued with negative thinking of self-underestimation. Again, introducing human special predispositions, the teachings provide him/her with a part of knowledge to the extension of option to control and manipulate the events, upon which one shuns the ego-centric interpretation of events. Furthermore, believing in the teachings and accepting them as true, the expectations and abilities would strike a balance as a result of which man sees him/herself free from the cases of ‘ought to’ and ‘ought not’. The cognitive approach to depression based on the anthropological verses of Quran is a new finding in the field of commentary. In addition, these Quran-based findings are a new solution to the personality disorder in the field of clinical psychology and counseling.