Self-forgetting has been regarded as one of important problems in anthropology and humanities. In the holy Quran, the phrase “soul-forgetting” and in other words, alienation that has been dealt with by philosophers and scholars of humanities. According to Quranic teachings, self-forgetting is a mental state that happens in human not in animals. Since it is only human being that is capable to his/her real essence with a kind of knowledge by presence, forget or sell it or become unfamiliar with it. The paper may be regarded as a Quranic applied study intending to study nature of self-forgetting and its pre-conditions in three fields of religious beliefs, ethics and deeds.