As is understood by the verses dealing with the Prophet`s time of mission at Mecca and historical clear signs, people of the Book lived in Mecca in a continuous interaction with the Prophet and Muslims. An interaction begun with Muslim`s glorifying people of the Book, answering their questions and agreeing with their authority in knowledge of the history of the past. Yet, it has referred to factions of people of the Book and their disagreements in understanding Torah and criticized a group with reproachful words. A critique being gradually increased when the two theist poles split up with one another and, following it, the verses of glorification decreased to such an extent that in the last part of revelation that a place for a quarrel between the Muslim and the people of the Book was made ready, Prophet`s community were ordered to avoid quarreling their theist enemies. One, therefore, may say that interactions between two poles of theism was positive during all time of Prophet`s mission in Mecca and as begun with glorifying believers of the people of the Book and ended with an order to Muslim to discuss them in the best way and emphasize what common with them.